SYNVISC® (hylan G-F 20)
SYNVISC 2ML is an elastoviscous high molecular weight fluid containing hylan A and hylan B polymers produced from chicken combs. Hylans are derivatives of hyaluronan (sodium hyaluronate). Hylan G-F 20 is unique in that the hyaluronan is chemically crosslinked. Hyaluronan is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-Nacetylglucosamine.
SYNVISC 2ML For 1 ml (Hylan G-F 20): hylan 8.0 mg, sodium chloride 8.5 mg, disodium phosphate 0.16 mg, sodium dihydrogen phosphate 0.04 mg, water for injections qs.
Hylan G-F is biologically similar to hyaluronan. Hyaluronan is a component of the synovial fluid that gives it its viscoelasticity. Hylane GF 20 has an elasticity (storage coefficient G ‘)
Instructions for use, Dosage:
Prior to injection, inform the patient that Synvisc and Synvisc-One consist of highly purified hyaluronic acid from an avian source.
Synvisc should only be administered intra-articularly and by a physician to relieve pain associated with osteoarthritis of the knee, hip, ankle and shoulder.
Use a needle of the appropriate diameter:
Synvisc: 18 to 22 gauges;
Use a needle of adequate length, depending on the joint to be treated.
Synvisc-One: 18 to 20 gauges.
Do not squeeze or exert excessive pressure to fix the needle or remove its sheath as this may break the tip of the syringe.
The contents of the syringe are for single use only. As recommended by the dosage, inject the entire volume of the syringe (2 ml for Synvisc and 6 ml for Synvisc-One). Discard any unused Synvisc / Synvisc-One product remaining.