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JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors,
with some selectivity for CB2. It produces effects in animals similar to those of (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis
products such as “legal cannabis herbal incense blends” which in some countries are sold legally as “incense”, labeled “not for human consumption”.

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Worried with your pain management, Buy buy jwh 018 online effective, potent, superlative fine quality JWH-018, a synthetic cannabinoid, more effective even than Tetrahydrocannabinol. The thing which makes it superior to other THC is that It has dual affinity for Cannabinoid receptors i.e.; CB-1 and CB-2 which make it a unique and quick relieving analgesic. 

JWH-018 is an analgesic drug. Basically it is considered as a map outed or synthetic cannabinoid. JWH-018 is used as an API (Active Pharmaceutical Ingredient) for those products which are used as a substituent of cannabis. JWH-018 has five times greater affinity for CB-1 receptors than THC but it is a full agonist for CB1 and CB-2 receptors. JWH-018 belongs to the naphthoylindole family. In scientific research of the cannabinoid system, JWH-018 is considered as a main tool. JWH-018 is hydrophobic in nature which means it is insoluble in water.

Name: JWH 018

Chemical Formula: C24H23NO

Routes of administration; Smoked, Oral

Legal status; Australia: schedule IX (Prohibited substance)

                       Canada: Schedule II

                       United Kingdom: Class B 

                       United states: Schedule I

Other Names: K2, fake weed, Yucatan fire, skunk, moon rocks

What is the Pharmacology of JWH-018?(buy jwh 018)

For CB-1 and CB-2 receptors, JWH-018 acts as a full agonist. But affinity for both receptors is totally different. For CB-1 receptors, it has affinity of 9.00 ± 5.00 nM, while for CB-2 receptors, the affinity value is 2.94 ± 2.65 nM. Same as in humans, JWh-018 has different Half-life effective concentration;

  • For CB-1 receptors, it is 102 nM
  • For CB-2 receptors, it 133 nM

 Recent researches show that JWH-018 has the same potency as Δ9-THC when they are examined in vivo. 

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What are the main uses of JWH-018?

It changes the density of CB-1 receptors’ density on administration making them resistant to other cannabinoids. 

Researchers advised those people who are suffering or suspected to suffer with psychotic illness, or if they have psychotic illness genetics, they should not use JWH-018.

There are several products which are sold as an alternative to cannabis substitutes, JWH-018 is used as an API in such products.

For CB-1 receptors in the brain, JWH-018 is one step ahead as compared to THC i.e.; JWH-018 is a full agonist while THC is a partial agonist. THC shows its effect by inhibiting gamma amino butyric acid (GABA) receptor neurotransmission by using different pathways. While JWH-018 shows its effect by acting on CB-1 and CB-2 receptors. It also has more effectivity for inhibiting GABA receptor neurotransmission compared to THC. As JWH-018 is more effective and potent, therefore, it is always advised to take a lower dose of JWH-018 in non-users because by using excessively in non-users, it will cause serious damages.

Main Advantage  (buy jwh 018)

The main advantage of smoking JWH-018 over Δ9-tetrahydrocannabinol (THC) is that JWH-018 in low dose produces exactly the same results as the high dose of Δ9-tetrahydrocannabinol (THC) produces. 

JWH-018 was analyzed in basic 

research of studying the relationship between structure and activity.


What are the effects of JWH-018 In mice? (buy jwh 018)

        It decreases 

  • overall activity, 
  • produces analgesia,
  • decreases body temperature
  • produces catalepsy.

  The above mentioned effects of JWH-018 are used to find out the Δ9-THC psychoactive effects in humans. In these four tests, researchers found out that JWh-018 and Δ9-THC have the same psychoactive effects in humans.

Buy online one of two types of products. One drug, same effect by two fully agonist ways. Get the same results with a low dose of JWH-018 by buying it online from us. We provide the best standard quality buy jwh 018

 

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